effect of wr-1065 on 6-hydroxydopamine-induced catalepsy and il-6 level in rats

Authors

afshin kheradmand drug applied research center, department of pharmacology and toxicology, tabriz university of medical sciences, tabriz, iran

alireza mohajjel nayebi drug applied research center, department of pharmacology and toxicology, tabriz university of medical sciences, tabriz, iran

department of pharmacology and toxicology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran

masoumeh jorjani department of pharmacology and neurobiology research center, faculty of medicine, shahid beheshti university of medical sciences, tehran, iran

abstract

objective(s): neuroinflammation and oxidative stress play a key role in pathogenesis of parkinson’s disease (pd). in the present study we investigated the effect of reactive oxygen species (ros) scavenger wr-1065 on catalepsy and cerebrospinal fluid (csf) level of interleukin 6(il-6) and striatum superoxide dismutase (sod) activity in 6-hydroxydopamine (6-ohda) induced experimental model of pd. materials and methods: seventy two male wistar rats were divided into 9 equal groups and 6-ohda (8 μg/2 μl/rat) was infused unilaterally into substantia nigra pars copmacta (snc) to induce pd. catalepsy was measured by standard bar test, csf level of il-6 was assessed by enzyme-linked immunosorbent assay (elisa) method and sod activity measured by spectrophotometric method. in pre-treatment groups wr-1065 (20, 40 and 80 μg/2 μl/rat/day, for 3 days) was infused into the snc before 6-ohda administration and 21 days later, as a recovery period, behavioral and molecular assay tests were done. results: our results showed that pre-treatment with wr-1065 improved (p<0.001) 6-ohda-induced catalepsy in a dose dependent manner. in 6-ohda-lesioned animals sod activity in snc and csf level of il-6 was decreased markedly (p<0.001) when compared with non-lesioned group, while pre-treatment with wr-1065(p<0.001) restored their levels up to the normal range. conclusion: our study indicated that pre-treatment with wr-1065 could modulate catalepsy and il-6 level in 6-ohda-lesioned rats. also wr1065 could increase sod activity up to normal range. it can be regarded as an anti-oxidative drug in prevention or adjunctive therapy of pd.

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Journal title:

iranian journal of basic medical sciences

جلد ۱۹، شماره ۵، صفحات ۴۹۰-۴۹۶

Keywords

[ ' c a t a l e p s y ' , ' i l ' , 6 , ' r a t ' , ' s o d ' , ' w r ' , 1 0 6 5 ]

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